General Information of Drug (ID: DMO0VGH)

Drug Name
Coenzyme Q10 analog Drug Info
Synonyms Coenzyme Q10 analog (mitochondrial disease); Coenzyme Q10 analog (mitochondrial disease), Edison Pharmaceuticals
Indication
Disease Entry ICD 11 Status REF
Huntington disease 8A01.10 Phase 2 [1]
Leigh syndrome 5C53.24 Phase 2 [2]
Mitochondrial respiratory chain disease 5C53.2 Phase 2 [2]
Rett syndrome LD90.4 Phase 2 [2]
Cross-matching ID
TTD Drug ID
DMO0VGH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting Quinone reductase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ARQ 761 DMH5CAL Pancreatic cancer 2C10 Phase 2 [4]
BioE-743 DM7PT8R Leigh syndrome 5C53.24 Phase 2 [5]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [6]
NSC-645808 DMMBAR3 Discovery agent N.A. Investigative [7]
NSC-106080 DMR6P9S Discovery agent N.A. Investigative [8]
NSC-99528 DMXZAIG Discovery agent N.A. Investigative [8]
NSC-354279 DMVL51I Discovery agent N.A. Investigative [7]
Duroquinone DML7YPS Discovery agent N.A. Investigative [6]
Ethyl Bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate DMJQTIK Discovery agent N.A. Investigative [9]
3-Benzyl-4-hydroxy-2H-benzo[h]chromen-2-one DMA5EHC Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Quinone reductase 1 (NQO1) TT8XK6L NQO1_HUMAN Modulator [3]

References

1 ClinicalTrials.gov (NCT02352896) Long-Term Safety and Efficacy Evaluation of EPI-743 in Children With Leigh Syndrome. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Therapeutic strategies for Leber's hereditary optic neuropathy: A current update. Intractable Rare Dis Res. 2013 November; 2(4): 130-135.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7 In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54.
8 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
9 Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56.