Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO37W4)

Drug Name

5-methyl-5-(5-methylthiophen-3-yl)-4-oxo-4,5-dihydrofuran-2-carboxylic acid Drug Info

Synonyms

compound 5aj [PMID: 17358052]

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Hydroxycarboxylic acid receptor 3 (HCAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARI-3037MO	DM9LNXS	Cardiovascular disease	BA00-BE2Z	Phase 2	[2]
NIA-114	DM3ADQW	Plaque psoriasis	EA90.0	Clinical trial	[3]
3-hydroxyoctanoic acid	DMS658R	Discovery agent	N.A.	Investigative	[4]
PMID17358052C5b	DMR9TYV	Discovery agent	N.A.	Investigative	[1]
D-tryptophan	DMKIML1	Discovery agent	N.A.	Investigative	[5]
D-kynurenine	DM0QZ6I	Discovery agent	N.A.	Investigative	[5]
4-(n-propyl)amino-3-nitrobenzoic acid	DMP43HI	Discovery agent	N.A.	Investigative	[6]
2-hydroxyoctanoic acid	DMMILJS	Discovery agent	N.A.	Investigative	[4]
PMID19524438C6o	DMK5JB8	Discovery agent	N.A.	Investigative	[7]
IBC 293	DM8J24A	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hydroxycarboxylic acid receptor 3 (HCAR3)	TT8WFXV	HCAR3_HUMAN	Agonist	[1]

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References

1	Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem. 2007 Apr 5;50(7):1445-8.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J Biol Chem. 2009 Aug 14;284(33):21928-33.
5	Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4.
6	3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6619-22.
7	5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4207-9.
8	1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J Med Chem. 2006 Feb 23;49(4):1227-30.