Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO9QB8)

Drug Name

R-IFN-1a Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Interferon alpha/beta receptor 1 (IFNAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EMZ701	DMDEL3F	Hepatitis B virus infection	1E51.0	Phase 2	[3]
MEDI-546	DMPKWR3	Ovarian cancer	2C73	Phase 2	[4]
Belerofon	DM9R0VA	Hepatitis C virus infection	1E51.1	Phase 1	[5]
Omega interferon	DMX6GFR	Hepatitis C virus infection	1E51.1	Discontinued in Phase 2	[6]
BLX-883	DMR7WYX	Hepatitis C virus infection	1E51.1	Discontinued in Phase 1	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interferon alpha/beta receptor 1 (IFNAR1)	TTSYFMA	INAR1_HUMAN	Modulator	[2]

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References

1	A phase II study of recombinant interferon-beta (r-hIFN-beta 1a) in combination with 5-fluorouracil (5-FU) in the treatment of patients with advanced colorectal carcinoma. Br J Cancer. 1997;75(3):423-6.
2	Further study on the specificity and incidence of neutralizing antibodies to interferon (IFN) in relapsing remitting multiple sclerosis patients treated with IFN beta-1a or IFN beta-1b. J Neurol Sci.1999 Oct 15;168(2):131-6.
3	Patent EP2766021 A1.
4	Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-alpha receptor 1 antibody. MAbs. 2015;7(2):428-39.
5	WO patent application no. 2009,0153,36, Controlled release interferon drug products and treatment of hcv infection using same.
6	Human interferon omega--a review. Mult Scler. 1995;1 Suppl 1:S44-7.
7	Patent CN103536906 A.