General Information of Drug (ID: DMO9S5P)

Drug Name
UCCF-029 Drug Info
Synonyms
2-Pyridin-4-yl-benzo[h]chromen-4-one; UCCF-029; 2110-25-0; CHEMBL177991; 2-(pyridin-4-yl)-4H-benzo[h]chromen-4-one; BAS 12813734; AC1MKUU0; MLS001209162; ZINC9006; SCHEMBL4069839; GTPL4335; CTK7H2722; DTXSID20390354; CHEBI:116557; HMS2841G23; BDBM50159612; 2-(4-pyridyl)benzo[h]chromen-4-one; 2-pyridin-4-ylbenzo[h]chromen-4-one; AKOS000507523; MCULE-4590967836; 2-(pyridin-4-yl)benzo[h]chromen-4-one; SMR000525005; TR-043515; ST50294170; EC-000.1914; 4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium; J-013846
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3163532
ChEBI ID
CHEBI:116557
CAS Number
CAS 2110-25-0
TTD Drug ID
DMO9S5P

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivacaftor DMZC1HS Cystic fibrosis CA25 Approved [3]
Crofelemer DM4AMQZ HIV-associated diarrhoea 1A2Z Approved [4]
Tezacaftor and ivacaftor DMY62FC Acute lung injury NB32.3 Approved [5]
VX-661 DMJBXO3 Cystic fibrosis CA25 Phase 3 [6]
ABBV-2222 DM4ZLTY Cystic fibrosis CA25 Phase 2 [7]
GLPG-1837 DMOCRYB Cystic fibrosis CA25 Phase 2 [7]
iOWH032 DM5TMYC Diarrhea ME05.1 Phase 2 [8]
Lumacaftor DMCLWDJ Cystic fibrosis CA25 Phase 2 [9]
QBW251 DMQ5APT Chronic obstructive pulmonary disease CA22 Phase 2 [10]
ABBV-3067 DMB01L5 Cystic fibrosis CA25 Phase 1 [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
cAMP-dependent chloride channel (CFTR) TTRLZHP CFTR_HUMAN Activator [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4335).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707).
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
5 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
6 CFTR Modulators for the Treatment of Cystic Fibrosis. P T. 2014 Jul;39(7):500-11.
7 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
8 Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25.
9 A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial. Lancet Respir Med. 2014 Jul;2(7):527-38.
10 Safety and efficacy of the cystic fibrosis transmembrane conductance regulator potentiator icenticaftor (QBW251). J Cyst Fibros. 2021 Mar;20(2):250-256.