General Information of Drug (ID: DMOAD2Y)

Drug Name
Dupilumab Drug Info
Synonyms REGN-668; REGN-668); Anti-IL-4 monoclonal antibody (asthma/atopic dermatitis), sanofi-aventis; Anti-IL-4 receptor antibody (VelocImmune, allergy/immune disorder), Regeneron/sanofi-aventis
Indication
Disease Entry ICD 11 Status REF
Atopic dermatitis EA80 Approved [1]
Asthma CA23 Phase 3 [2]
Cross-matching ID
TTD Drug ID
DMOAD2Y

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SAR231893 DMHFBOG Asthma CA23 Phase 3 [3]
CBP-201 DMWYNN1 Atopic dermatitis EA80 Phase 3 [4]
Aerovant DMUB8WN Asthma CA23 Phase 2a [5]
SAR-156597 DMUICJD Idiopathic pulmonary fibrosis CB03.4 Phase 2 [6]
PRX-321 DM7YWVT Solid tumour/cancer 2A00-2F9Z Phase 2 [7]
Altrakincept DMLSK01 Asthma CA23 Phase 2 [8]
AZD1402 DM73O6I Asthma CA23 Phase 2 [9]
AMG 317 DMUO3T2 Asthma CA23 Discontinued in Phase 1 [10]
PRS-060 DM8GCHX Asthma CA23 Investigative [6]
APG-201 DM0BVJN Solid tumour/cancer 2A00-2F9Z Investigative [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin 4 receptor alpha (IL4R) TTDWHC3 IL4RA_HUMAN Not Available [3]

References

1 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7574).
3 Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med. 2013 Jun 27;368(26):2455-66.
4 Preclinical immunological characterization of rademikibart (CBP-201), a next-generation human monoclonal antibody targeting IL-4Ralpha, for the treatment of Th2 inflammatory diseases. Sci Rep. 2023 Jul 31;13(1):12411.
5 Aerovance starts trial of Aerovant for uncontrolled asthma. Aerovance. March 3, 2009.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1697).
7 Convection-enhanced drug delivery of interleukin-4 Pseudomonas exotoxin (PRX321): increased distribution and magnetic resonance monitoring. J Pharmacol Exp Ther. 2009 Aug;330(2):520-5.
8 The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72.
9 Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma. J Allergy Clin Immunol. 2023 Apr;151(4):966-975.
10 Clinical pipeline report, company report or official report of Amgen (2009).