Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOALVR)

Drug Name
GSK-2485852 Drug Info
Synonyms
GL-60667; GSK-2485852A; NVP-LDI133; HCV RNA polymerase inhibitors, Genelabs/Novartis; NS5b non-nucleoside inhibitors (HCV infection), GSK/Novartis; NS5b non-nucleoside inhibitors (HCV), Genelabs/Novartis
Indication
Disease Entry ICD 11 Status REF
Hepatitis C virus infection 1E51.1 Terminated [1]
Cross-matching ID
PubChem CID
53354790
CAS Number
CAS 1331942-30-3
TTD Drug ID
DMOALVR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PSI-7977 DMLSUWZ HCV 1-6 infection 1E51 Approved [3]
Setrobuvir DMTNDM2 Hepatitis C virus infection 1E51.1 Phase 2 [4]
BI 207127 DMMSGAT Hepatitis C virus infection 1E51.1 Phase 2 [5]
Valopicitabine dihydrochloride DMFWZ2U Virus infection 1A24-1D9Z Phase 2 [6]
INX-189 DMSTJ6Q Hepatitis C virus infection 1E51.1 Phase 2 [7]
Tegobuvir DM6YI5T Hepatitis C virus infection 1E51.1 Phase 2 [8]
VX-759 DMJUSM8 Hepatitis C virus infection 1E51.1 Phase 2 [9]
VX-135 DMZ3FE8 Hepatitis C virus infection 1E51.1 Phase 2 [10]
VX-222 DMO3U4W Hepatitis C virus infection 1E51.1 Phase 2 [9]
BMS 791325 DMKH4PI Hepatitis C virus infection 1E51.1 Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) TTMVBWH POLG_HCV1 Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024593)
2 In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2013 Nov;57(11):5216-24.
3 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
4 Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011).
5 2011 Pipeline of Boehringer Ingelheim Pharma.
6 Valopicitabine dihydrochloride:a specific polymerase inhibitor of hepatitis C virus. Curr Opin Investig Drugs. 2007 Feb;8(2):150-8.
7 Clinical pipeline report, company report or official report of Bristol-Myers Squibb.
8 Clinical pipeline report, company report or official report of Gilead (2011).
9 2011 Pipeline of Vertex.
10 All-oral HCV therapies near approval. Nat Rev Drug Discov. 2013 Jun;12(6):409-11.
11 2011 Pipeline of Bristol-Myers Squibb.