Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOC1BX)

Drug Name

Paraldehyde Drug Info

Synonyms

UNII-S6M3YBG8QA; S6M3YBG8QA

Indication

Disease Entry	ICD 11	Status	REF
Insomnia	7A00-7A0Z	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Aldehyde dehydrogenase 2 (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[3]
Silodosin	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[4]
Amyl nitrite	DMJKO05	Angina pectoris	BA40	Approved	[5]
Pentaerythritol tetranitrate	DMZ9MO5	Angina pectoris	BA40	Approved	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Aldehyde dehydrogenase 2 (ALDH2)^{Main DME}	DEWYTJB	ALDH2_HUMAN	Substrate	[2]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Paraldehyde. J Appl Toxicol. 1991 Oct;11(5):379-81.
3	Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. Toxicol Appl Pharmacol. 1995 Aug;133(2):295-304.
4	Pharmacokinetics and disposition of silodosin (KMD-3213). Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45.
5	Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H819-26.
6	OSHA Occupational Chemical Database: drug information.