Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOGD42)

Drug Name

9-[2-(1-Phosphonobutan-2-yloxy)ethyl]guanine Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9200020, Table 3, Compound 1B	DMEARS2	N. A.	N. A.	Patented	[2]
US9200020, Table 3, Compound 2B	DMXFB5Z	N. A.	N. A.	Patented	[2]
US9200020, Table 3 compound 8	DMCLHX5	N. A.	N. A.	Patented	[2]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[3]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[3]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[4]
Guanosine-5'-Monophosphate	DM3SLZK	Discovery agent	N.A.	Investigative	[3]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[3]
Alpha-Phosphoribosylpyrophosphoric Acid	DMT6KI7	Discovery agent	N.A.	Investigative	[4]
Carboxylic PRPP	DMCTUR1	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)	TTBL49X	HGXR_PLAFG	Inhibitor	[1]

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References

1	Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum h... Bioorg Med Chem. 2009 Sep 1;17(17):6218-32.
2	6-oxopurine phosphoribosyltransferase inhibitors. US9200020.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.