Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOGDCQ)

Drug Name

Ab-01 Drug Info

Synonyms

Ab-02; IL-21 receptor-targeted human monoclonal antibodies (inflammation); Anti-IL-21R mAb (inflammation), Pfizer; IL-21 receptor-targeted human monoclonal antibodies (inflammation), Pfizer

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMOGDCQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Interleukin 21 receptor (IL21R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ATR-107	DMBCATZ	Crohn disease	DD70	Phase 1	[3]
AMG 256	DMXYCZV	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 21 receptor (IL21R)	TTZO9B0	IL21R_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT00447837) Evaluating SPRC-AB01 in Post-Surgical Subjects With Chronic Sinusitis. U.S. National Institutes of Health.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2304).
3	Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study. J Clin Pharmacol. 2014 Jan;54(1):14-22.
4	Clinical pipeline report, company report or official report of Amgen.