Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOI7ME)

Drug Name

5-Fluoro-2-hydroxy-N-isopropyl-benzamide Drug Info

Synonyms

CHEMBL84730; 5-Fluoro-2-hydroxy-N-isopropyl-benzamide; BDBM50084016; AKOS018088189

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Fungal Scytalone dehydratase (Fung SDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(3-Phenyl-propyl)-quinazolin-4-yl-amine	DM1C90Y	Discovery agent	N.A.	Investigative	[2]
Isoquinolin-1-yl-(3-phenyl-propyl)-amine	DMDF26N	Discovery agent	N.A.	Investigative	[2]
Carpropamid	DMBKQ03	Discovery agent	N.A.	Investigative	[3]
2-Hydroxy-N-(3-phenyl-propyl)-benzamide	DMWSR13	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fungal Scytalone dehydratase (Fung SDH1)	TT64EPS	SCYD_MAGO7	Inhibitor	[1]

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References

1	Binding dynamics of two water molecules constrained within the scytalone dehydratase binding pocket. Bioorg Med Chem Lett. 2000 Jan 3;10(1):23-6.
2	A diazine heterocycle replaces a six-membered hydrogen-bonded array in the active site of scytalone dehydratase, Bioorg. Med. Chem. Lett. 3(8):1605-1608 (1993).
3	Enzymatic characterization of scytalone dehydratase Val75Met variant found in melanin biosynthesis dehydratase inhibitor (MBI-D) resistant strains of the rice blast fungus. Biosci Biotechnol Biochem.2004 Mar;68(3):615-21.