General Information of Drug (ID: DMOJ7QA)

Drug Name
Mitemcinal fumarate Drug Info
Synonyms
(2S,4R,5R,8R,9S,10S,11R,12R)-5-ethyl-9-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-11-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-4-methoxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)-ene-3,7-dione
Indication
Disease Entry ICD 11 Status REF
Pain MG30-MG3Z Phase 2 [1]
Cross-matching ID
PubChem CID
11513721
CAS Number
CAS 154802-96-7
TTD Drug ID
DMOJ7QA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug(s) Targeting Motilin receptor (MLNR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MOTILIN DMVILAD N. A. N. A. Phase 4 [3]
Camicinal DMAKSMX Delayed gastric emptying DA41.00 Phase 2 [4]
RWJ-68023 DM4O07Q Irritable bowel syndrome DD91.0 Phase 1 [5]
KOS-2187 DM4953W Gastroesophageal reflux disease DA22.Z Phase 1 [6]
DS-3801 DM6WN9X Constipation DD91.1 Phase 1 [7]
GSK-1322888 DMNYGB8 Gastroparesis DA41.00 Phase 1 [8]
KW-5139 DMLOKXI Pain MG30-MG3Z Discontinued in Phase 2 [9]
KC-11458 DMOITN2 Gastric motility disorder DA21 Discontinued in Phase 2 [10]
SLV-305 DMBZM0D Gastric motility disorder DA21 Discontinued in Phase 2 [4]
SLV-311 DM5TJIY Gastrointestinal disease DE2Z Discontinued in Phase 1 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Motilin receptor (MLNR) TT953CX MTLR_HUMAN Agonist [2]

References

1 ClinicalTrials.gov (NCT00050882) Safety and Effectiveness of an Investigational Agent (GM-611) in Patients With Diabetic Gastroparesis. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Roche (2009).
3 Discovery of a new class of macrocyclic antagonists to the human motilin receptor. J Med Chem. 2006 Nov 30;49(24):7190-7.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297).
5 Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function. Br J Clin Pharmacol. 2004 Apr;57(4):393-401.
6 Kosan Announces Selection of KOS-2187 As Motilide Clinical Candidate at World Congress of Gastroenterology Meeting. Kosan. 2006.
7 Clinical pipeline report, company report or official report of Daiichi Sankyo.
8 ClinicalTrials.gov (NCT01294566) FTIH to Evaluate Safety, Tolerability, and Pharmacokinetics of Single Oral Doses of GSK1322888 in Healthy Caucasian and Japanese Volunteers. U.S. National Institutes of Health.
9 Stimulating action of KW-5139 (Leu13-motilin) on gastrointestinal motility in the rabbit. Br J Pharmacol. 1994 Jan;111(1):288-94.
10 Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis. Aliment Pharmacol Ther. 2004 Aug 1;20(3):333-8.
11 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017412)