Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOP8IJ)

• Drug Name: OAG Drug Info
• Synonyms: 1-oleoyl-2-acetyl-sn-glycerol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5353264
  TTD Drug ID: DMOP8IJ

Molecule-Related Drug Atlas

Drug(s) Targeting Short transient receptor potential channel 7 (TRPC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Short transient receptor potential channel 2 (TRPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[2]
SAG	DMHOG7W	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Short transient receptor potential channel 3 (TRPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[6]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[7]
KB-R7943	DMMD5W3	Discovery agent	N.A.	Investigative	[7]
BTP2	DMNM63G	Discovery agent	N.A.	Investigative	[8]
Pyr3	DM3VNYQ	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Short transient receptor potential channel 6 (TRPC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[10]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[10]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[10]
KB-R7943	DMMD5W3	Discovery agent	N.A.	Investigative	[10]
flufenamate	DMN8AP0	Discovery agent	N.A.	Investigative	[10]
SAG	DMHOG7W	Discovery agent	N.A.	Investigative	[3]
ML9	DMP13VE	Discovery agent	N.A.	Investigative	[10]
hyp 9	DM0U8IV	Discovery agent	N.A.	Investigative	[11]
SLG	DMEBPCO	Discovery agent	N.A.	Investigative	[3]
20-HETE	DM5BAJ9	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Short transient receptor potential channel 2 (TRPC2)	TTSJ9E7	Q3C1U7_HUMAN	Activator	[2]
Short transient receptor potential channel 3 (TRPC3)	TTNVC34	TRPC3_HUMAN	Activator	[3]
Short transient receptor potential channel 6 (TRPC6)	TTRBT3W	TRPC6_HUMAN	Activator	[3]
Short transient receptor potential channel 7 (TRPC7)	TT06GRA	TRPC7_HUMAN	Activator	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2436).
• [2] A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003 Oct 30;40(3):551-61.
• [3] Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63.
• [4] Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem. 1999 Sep 24;274(39):27359-70.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 492).
• [6] Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. Mol Pharmacol. 2005 Sep;68(3):758-62.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488).
• [8] A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J Biol Chem. 2005 Mar 25;280(12):10997-1006.
• [9] Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5.
• [10] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491).
• [11] Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore. Mol Pharmacol. 2010 Mar;77(3):368-77.