General Information of Drug (ID: DMOP8IJ)

Drug Name
OAG Drug Info
Synonyms 1-oleoyl-2-acetyl-sn-glycerol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5353264
TTD Drug ID
DMOP8IJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-APB DM9AKVR Discovery agent N.A. Investigative [5]
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-APB DM9AKVR Discovery agent N.A. Investigative [2]
SAG DMHOG7W Discovery agent N.A. Investigative [2]
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-APB DM9AKVR Discovery agent N.A. Investigative [6]
ACAA DMACYPW Discovery agent N.A. Investigative [7]
KB-R7943 DMMD5W3 Discovery agent N.A. Investigative [7]
BTP2 DMNM63G Discovery agent N.A. Investigative [8]
Pyr3 DM3VNYQ Discovery agent N.A. Investigative [9]
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-APB DM9AKVR Discovery agent N.A. Investigative [10]
lysophosphatidylcholine DMOGFVH Discovery agent N.A. Investigative [10]
ACAA DMACYPW Discovery agent N.A. Investigative [10]
KB-R7943 DMMD5W3 Discovery agent N.A. Investigative [10]
flufenamate DMN8AP0 Discovery agent N.A. Investigative [10]
SAG DMHOG7W Discovery agent N.A. Investigative [3]
ML9 DMP13VE Discovery agent N.A. Investigative [10]
hyp 9 DM0U8IV Discovery agent N.A. Investigative [11]
SLG DMEBPCO Discovery agent N.A. Investigative [3]
20-HETE DM5BAJ9 Discovery agent N.A. Investigative [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Short transient receptor potential channel 2 (TRPC2) TTSJ9E7 Q3C1U7_HUMAN Activator [2]
Short transient receptor potential channel 3 (TRPC3) TTNVC34 TRPC3_HUMAN Activator [3]
Short transient receptor potential channel 6 (TRPC6) TTRBT3W TRPC6_HUMAN Activator [3]
Short transient receptor potential channel 7 (TRPC7) TT06GRA TRPC7_HUMAN Activator [4]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2436).
2 A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003 Oct 30;40(3):551-61.
3 Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63.
4 Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem. 1999 Sep 24;274(39):27359-70.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 492).
6 Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. Mol Pharmacol. 2005 Sep;68(3):758-62.
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488).
8 A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J Biol Chem. 2005 Mar 25;280(12):10997-1006.
9 Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5.
10 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491).
11 Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore. Mol Pharmacol. 2010 Mar;77(3):368-77.