Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOP941)

• Drug Name: aspirin-triggered resolvin D1 Drug Info
• Synonyms: AT-Resolvin D1; AT-RvD1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 16126783
  ChEBI ID: CHEBI:138179
  CAS Number: CAS 528583-91-7
  TTD Drug ID: DMOP941

Molecule-Related Drug Atlas

Drug(s) Targeting Transient receptor potential cation channel V3 (TRPV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SAR292833	DM63QY0	Pain	MG30-MG3Z	Phase 2	[4]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[5]
diphenylboronic anhydride	DMRQZTS	Discovery agent	N.A.	Investigative	[6]
citral	DM53ZGY	Discovery agent	N.A.	Investigative	[7]
carvacrol	DMINM2D	Discovery agent	N.A.	Investigative	[8]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[9]
diphenyltetrahydrofuran	DMK8T61	Discovery agent	N.A.	Investigative	[6]
carveol	DMGIZ5U	Discovery agent	N.A.	Investigative	[10]
dihydrocarveol	DMS4U68	Discovery agent	N.A.	Investigative	[10]
tetrahydrocannabivarin	DMDY1MZ	Discovery agent	N.A.	Investigative	[11]

Drug(s) Targeting FMLP-related receptor I (FPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
humanin	DMUAPNF	Alzheimer disease	8A20	Preclinical	[12]
[3H]resolvin D1	DMFT0HU	Discovery agent	N.A.	Investigative	[13]
LXA4	DMGSVL0	Discovery agent	N.A.	Investigative	[13]
PMID22607879CR-(-)-5f	DM7OJ5Q	Discovery agent	N.A.	Investigative	[14]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[15]
RvD1-ME	DM8EZTM	Discovery agent	N.A.	Investigative	[2]
pyrazolone, 1	DMLFQKU	Discovery agent	N.A.	Investigative	[16]
quin-C7	DM1CYWB	Discovery agent	N.A.	Investigative	[17]
aspirin triggered lipoxin A4	DMLBSNP	Discovery agent	N.A.	Investigative	[18]
quin-C1	DMVQYWS	Discovery agent	N.A.	Investigative	[19]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
FMLP-related receptor I (FPR2)	TTOJ1NF	FPR2_HUMAN	Agonist	[2]
Transient receptor potential cation channel V3 (TRPV3)	TT946IA	TRPV3_HUMAN	Blocker (channel blocker)	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6239).
• [2] Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May;180(5):2018-27.
• [3] 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92.
• [4] Pharmacological profiling of the TRPV3 channel in recombinant and native assays. Br J Pharmacol. 2014 May;171(10):2631-44.
• [5] 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci. 2004 Jun 2;24(22):5177-82.
• [6] Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J Biol Chem. 2005 Apr 22;280(16):15928-41.
• [7] Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 7;3(5):e2082.
• [8] Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-35.
• [9] More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci. 2006 Aug;32(4):335-43.
• [10] Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40.
• [11] Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation. Acta Physiol (Oxf). 2012 Feb;204(2):255-66.
• [12] N-Formylated humanin activates both formyl peptide receptor-like 1 and 2. Biochem Biophys Res Commun. 2004 Nov 5;324(1):255-61.
• [13] Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5.
• [14] Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists. Bioorg Med Chem. 2012 Jun 15;20(12):3781-92.
• [15] Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors. J Biol Chem. 1993 Aug 25;268(24):18167-75.
• [16] Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8.
• [17] Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol Pharmacol. 2007 Oct;72(4):976-83.
• [18] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 223).
• [19] A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol Pharmacol. 2004 Nov;66(5):1213-22.