Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOSRET)

Drug Name

1DMe Drug Info

Synonyms

[D.Tyr1,(N.Me)Phe3]NPFF; [D-Tyr1,(NMe)Phe3]neuropeptide FF

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Neuropeptide FF receptor 1 (NPFFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RF9	DM3IXEA	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Neuropeptide FF receptor 2 (NPFFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RF9	DM3IXEA	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuropeptide FF receptor 1 (NPFFR1)	TTEP027	NPFF1_HUMAN	Agonist	[2]
Neuropeptide FF receptor 2 (NPFFR2)	TTXYNDJ	NPFF2_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1477).
2	Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [(125I]EYF as selective radioligands. Neuroscience. 2002;115(2):349-61.
3	RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71.