Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOSTP9)

Drug Name

SM-337 Drug Info

Synonyms

SM-337; CHEMBL504559; GTPL7732; SCHEMBL12851753; BDBM50273699; (5S,8S,10aR)-N-benzhydryl-5-[[(2S)-2-(methylamino)propanoyl]amino]-6-oxo-3-(2-phenylacetyl)-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 25172871
CAS Number: CAS 1071992-61-4
TTD Drug ID: DMOSTP9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Apoptosis-2 messenger RNA (BIRC3 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SM-131	DMP8VO6	Discovery agent	N.A.	Investigative	[3]
SM-122	DMC7YQE	Discovery agent	N.A.	Investigative	[2]
ISIS 23452	DM17G39	Discovery agent	N.A.	Investigative	[4]
ISIS 23454	DM7FPZV	Discovery agent	N.A.	Investigative	[4]
ISIS 23459	DM4PGRU	Discovery agent	N.A.	Investigative	[4]
ISIS 23414	DMOC0DT	Discovery agent	N.A.	Investigative	[4]
ISIS 23416	DMHQD76	Discovery agent	N.A.	Investigative	[4]
ISIS 23412	DMJ0LB1	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting XIAP messenger RNA (XIAP mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ASTX660	DMMKW8L	Lymphoma	2A80-2A86	Phase 2	[5]
AEG35156	DM2HRYD	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[6]
EMBELIN	DMFZO4Y	N. A.	N. A.	Terminated	[7]
AZD5582	DMPIHN6	Discovery agent	N.A.	Investigative	[8]
SM-131	DMP8VO6	Discovery agent	N.A.	Investigative	[3]
BV-6	DMDTV7A	Discovery agent	N.A.	Investigative	[9]
SM-122	DMC7YQE	Discovery agent	N.A.	Investigative	[2]
ARPFAQK-FAM	DMU70YP	Discovery agent	N.A.	Investigative	[7]
AVPIAQKSEK-FAM	DMNQ9R4	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis-2 messenger RNA (BIRC3 mRNA)	TTAIWZN	BIRC3_HUMAN	Inhibitor	[2]
XIAP messenger RNA (XIAP mRNA)	TTK3WBU	XIAP_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7732).
2	Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7.
3	Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of ca... J Med Chem. 2008 Dec 11;51(23):7352-5.
4	US patent application no. 5,958,771, Antisense modulation of cellular inhibitor of Apoptosis-2 expression.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Teaming up to tackle RNAi delivery challenge. Nat Rev Drug Discov. 2009 Jul;8(7):525-6.
7	Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional... J Med Chem. 2004 May 6;47(10):2430-40.
8	Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.
9	IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81.