Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOT0WR)

Drug Name

ONO-2333Ms Drug Info

Synonyms

Corticotropin-releasing factor-1 antagonist (oral, anxiety/depression), Ono

Indication

Disease Entry	ICD 11	Status	REF
Anxiety disorder	6B00-6B0Z	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting Corticotropin-releasing factor receptor 1 (CRHR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Telavancin	DM58VQX	Staphylococcus infection	1B5Y	Approved	[3]
Pexacerfont	DMBJ15R	Anxiety disorder	6B00-6B0Z	Phase 2/3	[4]
SSR125543	DMGJEB8	Anxiety disorder	6B00-6B0Z	Phase 2	[5]
GSK561679	DMEVARK	Alcohol dependence	6C40.2	Phase 2	[6]
Tildacerfont	DMAB8LH	Congenital adrenal hyperplasia	5A71.01	Phase 2	[7]
GSK586529	DM5E9LX	Anxiety disorder	6B00-6B0Z	Phase 1	[6]
GW876008	DMAXRBI	Irritable bowel syndrome	DD91.0	Discontinued in Phase 2	[4]
CP-316,311	DMZ76EM	Major depressive disorder	6A70.3	Discontinued in Phase 2	[4]
CRA1000	DMWMBIV	Anxiety disorder	6B00-6B0Z	Preclinical	[3]
NBI-37582	DM3JY2N	Anxiety disorder	6B00-6B0Z	Terminated	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticotropin-releasing factor receptor 1 (CRHR1)	TT7EFHR	CRFR1_HUMAN	Antagonist	[2]

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References

1	ClinicalTrials.gov (NCT00514865) Placebo-Controlled Study of ONO-2333Ms in Patients With Recurrent Major Depressive Disorder. U.S. National Institutes of Health.
2	Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug Alcohol Depend. 2013 Mar 1;128(3):175-86.
3	A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68.
4	Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
5	Pharma & Vaccines. Product Development Pipeline. April 29 2009.
6	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
7	Clinical advances in the pharmacotherapy of congenital adrenal hyperplasia. Eur J Endocrinol. 2021 Nov 30;186(1):R1-R14.
8	CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.