Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOWEBU)

Drug Name

Pegaptanib Drug Info

Synonyms

Macugen (TN); Pegaptanib Octasodium; Pegaptanib sodium; EYE 001; NX 1838; NX1838

Indication

Disease Entry	ICD 11	Status	REF
Neovascular age-related macular degeneration	9B78.3Z	Approved	[1]

Therapeutic Class

Antiangiogenic Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Neuropilin-1 (NRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RG7347	DMOE5NQ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
ASP1948	DMC80LV	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
H-KPPR-OH	DMDINX9	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6836).
2	Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov. 2006 Feb;5(2):123-32.
3	Neuropilin-1 as Therapeutic Target for Malignant Melanoma. Front Oncol. 2015; 5: 125.
4	National Cancer Institute Drug Dictionary (drug name ASP1948).
5	Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26.