Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOWINT)

Drug Name

Reloxaliase Drug Info

Synonyms

ALLN-177

Indication

Disease Entry	ICD 11	Status	REF
Hyperoxaluria	5C51.2	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

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Drug(s) Targeting Oxalate absorption (Oxalate absor)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALTU-237	DMS5C06	Hyperoxaluria	5C51.2	Discontinued in Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxalate absorption (Oxalate absor)	TTMDQIJ	NOUNIPROTAC	Replacement	[2]

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References

1	ClinicalTrials.gov (NCT03847090) Establishing the Safety and Efficacy of Reloxaliase in Patients With Enteric Hyperoxaluria (URIROX-2). U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Allena Pharmaceuticals.
3	Hyperoxaluria: a gut-kidney axis. Kidney Int. 2011 Dec;80(11):1146-58.