Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOX8FD)

• Drug Name: KELATORPHAN Drug Info
• Synonyms: kelatorphan; 92175-57-0; UNII-46BBW2U5D6; n-[(2r)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]-l-alanine; 46BBW2U5D6; (3-(N-Hydroxy)carboxamido-2-benzylpropanoyl)alanine; L-Alanine, N-(4-(hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl)-, (R)-; 3b7u; AC1L3XO7; CHEMBL85320; SCHEMBL7384459; BDBM92500; DTXSID90238911; ZINC6020153; DB08040; HY-10827; KB-78017; LS-186814; LS-187482; CS-0002846; (2S)-2-[[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]amino]propanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 123982
  CAS Number: CAS 92175-57-0
  TTD Drug ID: DMOX8FD

Molecule-Related Drug Atlas

Drug(s) Targeting Glutamyl aminopeptidase (ENPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
QGC-001	DMAFUHK	Hypertension	BA00-BA04	Phase 2	[2]
PMID10602705C40	DMLH73O	Discovery agent	N.A.	Investigative	[3]
EC33	DM67549	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting Aminopeptidase N (ANPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IP10 C8	DMANRGW	Psoriasis vulgaris	EA90	Phase 2	[5]
[(125)I] RB129	DMX0G7E	Discovery agent	N.A.	Investigative	[6]
(1-Amino-3-phenyl-propyl)-phosphinic acid	DMXD697	Discovery agent	N.A.	Investigative	[7]
N1-(3,3-diphenylpropyl)-N3-hydroxymalonamide	DM5F04D	Discovery agent	N.A.	Investigative	[8]
N1-(4-chlorobenzyl)-2-benzyl-N3-hydroxymalonamide	DMTMDZ4	Discovery agent	N.A.	Investigative	[8]
N1,2-dibenzyl-N3-hydroxy-N1-phenethylmalonamide	DM1L89K	Discovery agent	N.A.	Investigative	[8]
1-aminohexylphosphonic acid	DMFUABI	Discovery agent	N.A.	Investigative	[9]
(S)-2-Amino-3-phenyl-propane-1-thiol	DMMAUKO	Discovery agent	N.A.	Investigative	[7]
(Amino-phenyl-methyl)-phosphinic acid	DMS4ZVK	Discovery agent	N.A.	Investigative	[7]
1-aminohexylphosphonic acid monophenyl ester	DML6UJM	Discovery agent	N.A.	Investigative	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aminopeptidase N (ANPEP)	TTPHMWB	AMPN_HUMAN	Inhibitor	[1]
Glutamyl aminopeptidase (ENPEP)	TT9PBIL	AMPE_HUMAN	Inhibitor	[1]

References

• [1] Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem. 1988 Sep;31(9):1825-31.
• [2] Clinical pipeline report, company report or official report of Quantum Genomics.
• [3] Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme. J Med Chem. 1999 Dec 16;42(25):5197-211.
• [4] Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure. Biochem Soc Trans. 2000;28(4):435-40.
• [5] Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin Chem Lab Med. 2009;47(3):253-61.
• [6] Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography. Biochimie. 2004 Feb;86(2):105-13.
• [7] Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6.
• [8] Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34.
• [9] New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2010 Apr 15;18(8):2930-6.