Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOZGBQ)

Drug Name

BI 1291583 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Non-cystic fibrosis bronchiectasis	CA24	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Dipeptidyl peptidase I (CTSC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK2793660	DMSGNVK	Bronchiectasis	CA24	Phase 1	[3]
GNF-PF-5434	DMP9AIH	Discovery agent	N.A.	Investigative	[4]
PMID3941405C3d	DM6ZOW4	Discovery agent	N.A.	Investigative	[5]
(S)-2-amino-N-(1-cyano-2-phenylethyl)acetamide	DMN1G8L	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT05238675) A Randomised, Double-blind, Placebo-controlled, Parallel Group, Dose-finding Study Evaluating Efficacy, Safety and Tolerability of BI 1291583 qd Over at Least 24 Weeks in Patients With Bronchiectasis (AirleafTM). U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of boehringer-ingelheim
3	ClinicalTrials.gov (NCT02058407) A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Food Effect of Single or Repeat Doses of GSK2793660 in Healthy Subjects. U.S. National Institutes of Health.
4	Substrate optimization for monitoring cathepsin C activity in live cells. Bioorg Med Chem. 2009 Feb 1;17(3):1064-70.
5	Carboxyl-modified amino acids and peptides as protease inhibitors. J Med Chem. 1986 Jan;29(1):104-11.
6	Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3614-7.