General Information of Drug (ID: DMP5A8K)

Drug Name
N-[5-(2-Ethyl-phenyl)-furan-2-carbonyl]-guanidine Drug Info
Synonyms CHEMBL372051; N-[5-(2-Ethyl-phenyl)-furan-2-carbonyl]-guanidine; SCHEMBL4939618
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11172909
TTD Drug ID
DMP5A8K

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zoniporide hydrochloride DM8L7JD Angina pectoris BA40 Phase 3 [2]
CARIPORIDE DMV2DY3 Angina pectoris BA40 Discontinued in Phase 2 [3]
ENIPORIDE DME7OCX Cardiac arrhythmias BC9Z Discontinued in Phase 2 [4]
HOE-694 DML0B97 Heart arrhythmia BC65 Terminated [5]
N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine DMSVQJP Discovery agent N.A. Investigative [5]
N-(4-Chloro-3-methanesulfonyl-benzoyl)-guanidine DMFG6MU Discovery agent N.A. Investigative [5]
N-(4-Cyano-3-methanesulfonyl-benzoyl)-guanidine DMGI9EA Discovery agent N.A. Investigative [5]
N-(4-Bromo-3-methanesulfonyl-benzoyl)-guanidine DMC28SN Discovery agent N.A. Investigative [5]
N-(3-Methanesulfonyl-4-methoxy-benzoyl)-guanidine DM0H8CK Discovery agent N.A. Investigative [5]
N-(5-Methanesulfonyl-2-methyl-benzoyl)-guanidine DM91463 Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium/hydrogen exchanger 1 (SLC9A1) TTGSEFH SL9A1_HUMAN Inhibitor [1]

References

1 (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91.
2 Zoniporde: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc Drug Rev. 2003 Spring;21(1):17-32.
3 Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives. Eur J Med Chem. 2009 Sep;44(9):3771-6.
4 Bicyclic acylguanidine Na+/H+ antiporter inhibitors. J Med Chem. 1998 Sep 10;41(19):3736-47.
5 (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34.