Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP5G1K)

Drug Name

KPS-0373 Drug Info

Synonyms

S-0373; TSH release modulator (spinocerebellar ataxia), Kissei; Thyrotropin-releasing hormone derivative (spinocerebellarataxia), Shionogi; Thyrotropin-releasing hormone derivative (Parkinson's disease), Shionogi

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Phase 3	[1]

Cross-matching ID

PubChem CID: 9951059
TTD Drug ID: DMP5G1K

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

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Drug(s) Targeting Thyrotropin-releasing hormone (TRH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RX-77368	DMR0K85	Dementia	6D80-6D86	Discontinued in Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thyrotropin-releasing hormone (TRH)	TT2Z39D	TRH_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01970111) An Extension Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD). U.S. National Institutes of Health.
2	DOI: 10.1002/mdc3.12057
3	Intracisternal urocortin inhibits vagally stimulated gastric motility in rats: role of CRF(2).Br J Pharmacol.2002 May;136(2):237-47.