General Information of Drug (ID: DMP8VO6)

Drug Name
SM-131 Drug Info
Synonyms CHEMBL514738
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44589292
TTD Drug ID
DMP8VO6

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SM-337 DMOSTP9 Discovery agent N.A. Investigative [2]
SM-122 DMC7YQE Discovery agent N.A. Investigative [2]
ISIS 23452 DM17G39 Discovery agent N.A. Investigative [3]
ISIS 23454 DM7FPZV Discovery agent N.A. Investigative [3]
ISIS 23459 DM4PGRU Discovery agent N.A. Investigative [3]
ISIS 23414 DMOC0DT Discovery agent N.A. Investigative [3]
ISIS 23416 DMHQD76 Discovery agent N.A. Investigative [3]
ISIS 23412 DMJ0LB1 Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ASTX660 DMMKW8L Lymphoma 2A80-2A86 Phase 2 [4]
AEG35156 DM2HRYD Solid tumour/cancer 2A00-2F9Z Phase 1/2 [5]
EMBELIN DMFZO4Y N. A. N. A. Terminated [6]
AZD5582 DMPIHN6 Discovery agent N.A. Investigative [7]
SM-337 DMOSTP9 Discovery agent N.A. Investigative [2]
BV-6 DMDTV7A Discovery agent N.A. Investigative [8]
SM-122 DMC7YQE Discovery agent N.A. Investigative [2]
ARPFAQK-FAM DMU70YP Discovery agent N.A. Investigative [6]
AVPIAQKSEK-FAM DMNQ9R4 Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Apoptosis-2 messenger RNA (BIRC3 mRNA) TTAIWZN BIRC3_HUMAN Inhibitor [1]
XIAP messenger RNA (XIAP mRNA) TTK3WBU XIAP_HUMAN Inhibitor [1]

References

1 Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of ca... J Med Chem. 2008 Dec 11;51(23):7352-5.
2 Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7.
3 US patent application no. 5,958,771, Antisense modulation of cellular inhibitor of Apoptosis-2 expression.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Teaming up to tackle RNAi delivery challenge. Nat Rev Drug Discov. 2009 Jul;8(7):525-6.
6 Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional... J Med Chem. 2004 May 6;47(10):2430-40.
7 Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.
8 IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81.