General Information of Drug (ID: DMPE2B9)

Drug Name
ZD-7288 Drug Info
Synonyms
N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine; AC1L3XOD; SCHEMBL9380740; GTPL2359; ZINC100058922; N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine; AKOS027381051; ZINC255004003
Indication
Disease Entry ICD 11 Status REF
Angina pectoris BA40 Phase 2 [1]
Cross-matching ID
PubChem CID
9796088
CAS Number
CAS 133059-99-1
TTD Drug ID
DMPE2B9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivabradine DM0L594 Angina pectoris BA40 Approved [3]
SKL-NP DMRHD6B Pain MG30-MG3Z Phase 2 [4]
Cilobradine DM7EAG8 Cardiac arrhythmias BC9Z Phase 1 [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hyperpolarization cyclic nucleotide-gated channel (HCN) TTKLW9S NOUNIPROTAC Modulator [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2359).
2 ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. World J Gastroenterol. 2014 Feb 28;20(8):2091-7.
3 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
4 A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons. Korean J Physiol Pharmacol. 2012 Aug;16(4):237-41.
5 Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.