General Information of Drug (ID: DMPM8VB)

Drug Name
US10053465, 12 Drug Info
Synonyms
SCHEMBL9894097; SCHEMBL9927070; SCHEMBL9894098; BDBM246873; US10053465, 12; {trans-3-(4-{[4- {[(2S)-2- (hydroxymethyl) pyrrolidin-1-yl] methyl}-6- (trifluoromethyl) pyridin-2- yl]oxy}piperidin-1- yl)-1-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]cyclobutyl} acetonitrile
Cross-matching ID
PubChem CID
67954458
TTD Drug ID
DMPM8VB

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RXDX-106 DM6NVTR Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
BDBM50444058 DM9GLQB N. A. N. A. Patented [3]
BDBM50444062 DMR2UGC N. A. N. A. Patented [3]
KRDULPYOVRWKMA-UHFFFAOYSA-N DMRY7KV N. A. N. A. Patented [4]
BDBM50444059 DMS0EMU N. A. N. A. Patented [3]
US10053465, 8 DM42XWO N. A. N. A. Patented [4]
US10053465, 5 DMV7BF2 N. A. N. A. Patented [1]
LDC1267 DMH7R6L Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TYRO3 tyrosine kinase receptor (TYRO3) TTIEMFN TYRO3_HUMAN Inhibitor [1]

References

1 Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors. US9708333.
2 National Cancer Institute Drug Dictionary (drug name RXDX106).
3 Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity. US9649309.
4 Pyrrolopyrimidine derivatives as TAM inhibitors. US10053465.
5 The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014 Mar 27;507(7493):508-12.