Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPV6B2)

Drug Name
BA-058 Drug Info
Synonyms BA-058 Microneedle Patch; BA-058 (transdermal microneedle patch, osteoporosis); BA-058 (transdermal microneedle patch, osteoporosis), Radius Health
Indication
Disease Entry ICD 11 Status REF
Osteoporosis FB83.0 Phase 3 [1]
Cross-matching ID
TTD Drug ID
DMPV6B2

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Parathyroid hormone receptor (PTH2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GSK768974 DMIEXUM Osteoporosis FB83.0 Phase 2 [3]
NPSP-795 DM3DQXG Osteoporosis FB83.0 Phase 2 [4]
UNI-PH (1-34) DM8LBUK Osteoporosis FB83.0 Phase 2 [5]
PTH(7-34) liposomal cream DMRQ5YT Alopecia ED70 Phase 1 [6]
Semparatide DMLK605 Osteoporosis FB83.0 Discontinued in Phase 2 [7]
BB-PTH 1-84 DM85AJ4 Osteoporosis FB83.0 Investigative [4]
PTHr pepducins DM10KIW Endocrine disease 5B3Z Investigative [4]
Hemoparatide DMF7X31 Discovery agent N.A. Investigative [8]
ZP-2307 DM8WRAU Osteoporosis FB83.0 Investigative [4]
SDZ-PTS-893 DMBYSEM Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Parathyroid hormone receptor (PTH2R) TTEPJL5 PTH2R_HUMAN Modulator [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8299).
2 Emerging therapies for the treatment of osteoporosis. J Midlife Health. 2013 Jul-Sep; 4(3): 147-152.
3 Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice. Bone. 2000 Oct;27(4):471-8.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 332).
5 Parathyroid hormone for the treatment of osteoporosis: a systematic review. CMAJ. 2006 July 4; 175(1): 52-59.
6 Differential effects of intermittent PTH(1-34) and PTH(7-34) on bone microarchitecture and aortic calcification in experimental renal failure. Bone. 2008 Dec;43(6):1022-30.
7 Quantitative cell membrane-based radioligand binding assays for parathyroid hormone receptors. J Pharmacol Toxicol Methods. 1999 Apr-Jun;41(2-3):83-90.
8 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
9 Long-term therapy of ovariectomy-induced osteopenia with parathyroid hormone analog SDZ PTS 893 and bone maintenance in retired breeder rats. Bone. 1999 Nov;25(5):561-9.