Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPWZCI)

Drug Name

CVT-1 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hypercholesterolaemia	5C80.0	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bile-salt-activated lipase (CEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bucelipase alfa	DM50SNX	Exocrine pancreatic insufficiency	DC35.1	Phase 3	[2]
Taurocholic Acid	DM2LZ8F	Type-2 diabetes	5A11	Phase 1/2	[3]
PMID24556381C10l	DMOH45T	Discovery agent	N.A.	Investigative	[4]
PMID24556381C10f	DMK6GAU	Discovery agent	N.A.	Investigative	[4]
TgBSSL	DMBFX7S	Pancreatic malfunction	DC30-DC3Z	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bile-salt-activated lipase (CEL)	TTTRNQW	CEL_HUMAN	Modulator	[1]

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References

1	Lack of effect of cholesterol esterase inhibitor CVT-1 on cholesterol absorption and LDL cholesterol in humans. Cardiovasc Drugs Ther. 1999 Sep;13(5):449-54.
2	ClinicalTrials.gov (NCT00743483) Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency. U.S. National Institutes of Health.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1545-9.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2872).