Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPZ67G)

Drug Name

SDZ-281-240 Drug Info

Synonyms

[1R,9S,12S(1'R,3'S),13R,14S,17R,21S,23S,24R,25S,27R]-17-Ethyl-1,14-dihydroxy-12-[2-[3-(hydroxymethyl)cyclopentyl]-1(E)-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22

Indication

Disease Entry	ICD 11	Status	REF
Pruritus	EC90	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMPZ67G

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting FK506-binding protein 1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GPI-1485	DM64ZYM	Parkinson disease	8A00.0	Phase 2	[2]
AP1903	DM2LU8M	Transplant rejection	NE84	Phase 1/2	[3]
Gpi-1046	DMD5WK4	Parkinson disease	8A00.0	Terminated	[4]
MYRISTIC ACID	DMYX0BL	Discovery agent	N.A.	Investigative	[4]
Heptyl-Beta-D-Glucopyranoside	DMPQBN0	Discovery agent	N.A.	Investigative	[5]
4-Hydroxy-2-Butanone	DM7BQ65	Discovery agent	N.A.	Investigative	[6]
L-709,587	DM9KCYQ	Discovery agent	N.A.	Investigative	[6]
Methyl Methylsulfinylmethyl Sulfide	DMOCXLW	Discovery agent	N.A.	Investigative	[6]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[6]
FKB-001	DM9K834	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
FK506-binding protein 1A (FKBP1A)	TTMW94E	FKB1A_HUMAN	Modulator	[1]

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References

1	Clearing of psoriasis by a novel immunosuppressive macrolide. J Invest Dermatol. 1996 Apr;106(4):701-10.
2	Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
3	Using gene transfer to circumvent off-target effects. Gene Ther. 2008 May;15(10):759-64.
4	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
5	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
6	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.