Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ1F7J)

Drug Name

ADP ribose Drug Info

Synonyms

ADP Ribose; ADPR (nucleotide); Adenosine diphosphoribose; Ribose adenosinediphosphate; Adenosine pyrophosphate-ribose; [32P]-ADP-ribose; AC1L1J3O; GTPL2444; Adenosine 5'-diphosphate, D-ribose ester; Adenosine 5'-diphosphate, D-ribose ester (6CI); Adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose (7CI); Ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate), D-; Adenosine 5'-(trihydrogen pyrophosphate), 5'-5-ester with D-ribofuranose; Adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribo

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 30243
CAS Number: CAS 20762-30-5
TTD Drug ID: DMQ1F7J

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Long transient receptor potential channel 2 (TRPM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[3]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[4]
NAADP	DM51DW6	Discovery agent	N.A.	Investigative	[5]
OAADPR	DM458IH	Discovery agent	N.A.	Investigative	[6]
GEA 3162	DMBGWEK	Discovery agent	N.A.	Investigative	[7]
cADPR	DMLKZQH	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Long transient receptor potential channel 2 (TRPM2)	TTEBMN7	TRPM2_HUMAN	Activator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2444).
2	ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature. 2001 May 31;411(6837):595-9.
3	Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br J Pharmacol. 2008 Mar;153(6):1324-30.
4	Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73.
5	Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J. 2006 May;20(7):962-4.
6	Metabolite of SIR2 reaction modulates TRPM2 ion channel. J Biol Chem. 2006 May 19;281(20):14057-65.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 494).