Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ789Z)

Drug Name
8H9 Drug Info
Indication
Disease Entry ICD 11 Status REF
Brain cancer 2A00 Phase 1 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Cross-matching ID
PubChem CID
164575500
TTD Drug ID
DMQ789Z

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tenascin (TNC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
F-16-IL-2 fusion protein DMJ4BKT Solid tumour/cancer 2A00-2F9Z Phase 2 [4]
F-16-131I DM49BX1 Haematological malignancy 2B33.Y Phase 1/2 [5]
131I-81C6 DMVO0LU Brain cancer 2A00 Terminated [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tenascin (TNC) TTUCPMY TENA_HUMAN Not Available [3]

References

1 ClinicalTrials.gov (NCT01502917) Convection-Enhanced Delivery of 124I-8H9 for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT01099644) Intraperitoneal Radioimmunotherapy With 131I-8H9 for Patients With Desmoplastic Small Round Cell Tumors and Other Solid Tumors Involving the Peritoneum. U.S. NationalInstitutes of Health.
3 In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma. Cancer Res. 2004 Feb 15;64(4):1419-24.
4 National Cancer Institute Drug Dictionary (drug id 674718).
5 Tumor-Associated Fibroblasts and their Matrix. Springer. Margareta M. Mueller,Norbert E. Fusenig, 2011. Page(775).
6 Human IgG2 constant region enhances in vivo stability of anti-tenascin antibody 81C6 compared with its murine parent. Clin Cancer Res. 1998 Oct;4(10):2495-502.