Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQAEU8)

Drug Name

EPIMER A Drug Info

Synonyms

CHEMBL564088; EPIMER A; BDBM50296787; N-((S)-2''-oxo-1,1'',2'',3-tetrahydrospiro[indene-2,3''-pyrrolo[2,3-b]pyridine]-5-yl)-2-(4-oxo-2a,3,4,5-tetrahydropyrrolo[4,3,2-de]quinolin-1(2H)-yl)acetamide 2; N-((S)-2''-oxo-1,1'',2'',3-tetrahydrospiro[indene-2,3''-pyrrolo[2,3-b]pyridine]-5-yl)-2-(4-oxo-2a,3,4,5-tetrahydropyrrolo[4,3,2-de]quinolin-1(2H)-yl)acetamide 1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 23582940
TTD Drug ID: DMQAEU8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Calcitonin gene-related peptide receptor (CGRPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ubrogepant	DM749I3	Migraine	8A80	Approved	[2]
Fremanezumab	DMDZY54	Hyperprolactinaemia	5A60.1	Approved	[3]
Galcanezumab	DMIZ1E8	Hyperprolactinaemia	5A60.1	Approved	[3]
Erenumab	DMWMCN0	Hyperprolactinaemia	5A60.1	Approved	[3]
Rimegepant	DMHOAUG	Migraine	8A80	Approved	[4]
MK-3207	DM6OLGC	Migraine	8A80	Phase 2	[5]
AMG 334	DMI3WFG	Migraine	8A80	Phase 2	[6]
Telcagepant	DMFT5D6	Cluster headache	8A81.0	Phase 2	[7]
Olcegepant	DMVW5KR	Migraine	8A80	Phase 2	[8]
BI-44370	DMZR9OU	Migraine	8A80	Phase 2	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcitonin gene-related peptide receptor (CGRPR)	TTY6O0Q	CALRL_HUMAN	Inhibitor	[1]

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References

1	The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4740-2.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
3	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
5	Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.
6	EHMTI-0315. AMG 334, the first potent and selective human monoclonal antibody antagonist against the CGRP receptor. J Headache Pain. 2014; 15(Suppl 1): G43.
7	CGRP antagonists: novel concept for treatment of migraine. Med Monatsschr Pharm. 2009 May;32(5):182-5.
8	Olcegepant, a non-peptide CGRP1 antagonist for migraine treatment. IDrugs. 2007 Aug;10(8):566-74.
9	BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study. Cephalalgia. 2011 Apr;31(5):573-84.