Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQBEYV)

• Drug Name: GC021109 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMQBEYV

Molecule-Related Drug Atlas

Drug(s) Targeting P2Y purinoceptor 6 (P2RY6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
INS 316	DMTHMEI	Lung cancer	2C25.0	Discontinued in Phase 3	[2]
adenosine diphosphate	DMFUHKP	N. A.	N. A.	Investigative	[2]
2MeSATP	DMUE0W6	Discovery agent	N.A.	Investigative	[2]
RB 2	DMCEFUW	Discovery agent	N.A.	Investigative	[3]
PSB-0952	DMW19LB	Discovery agent	N.A.	Investigative	[3]
5BrUTP	DMEVRH4	Discovery agent	N.A.	Investigative	[2]
MRS2782	DMZSO4R	Discovery agent	N.A.	Investigative	[4]
MRS2578	DMKMPS6	Discovery agent	N.A.	Investigative	[5]
UDP-beta-S	DMMWHAV	Discovery agent	N.A.	Investigative	[6]
Up3U	DMKQWSB	Discovery agent	N.A.	Investigative	[6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
P2Y purinoceptor 6 (P2RY6)	TTNVSKA	P2RY6_HUMAN	Agonist	[1]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8.
• [3] Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86.
• [4] Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg Med Chem. 2008 Jun 15;16(12):6319-32.
• [5] Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol. 2004 May 1;67(9):1763-70.
• [6] P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13(3):289-312.