General Information of Drug (ID: DMQKMX3)

Drug Name
alpha-propyldopacetamide Drug Info
Synonyms
alpha-Propyldopacetamide; 2-(3,4-Dihydroxyphenyl)pentanamide; 154-62-1; a-propyldopacetamide; Dihydroxyphenylvaleramide; EINECS 205-830-9; Benzeneacetamide,3,4-dihydroxy-a-propyl-,(aR)-; Benzeneacetamide,3,4-dihydroxy-a-propyl-,(aS)-; .alpha.-Propyldopacetamide; ACMC-20mn67; ACMC-20mn66; AC1Q5IT3; AC1L2R8E; GTPL5095; CTK8G6411; GDXQWRJYXZXWMT-UHFFFAOYSA-N; MolPort-003-894-618; KUC106729N; 2-(3,4-Dihydroxyphenyl)valeramide; AKOS024285098; a-propyl-3,4-dihydroxyphenyl-acetamide; MCULE-1302132273
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
101635
CAS Number
CAS 154-62-1
TTD Drug ID
DMQKMX3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Phenylalanine DMQXI9F Malnutrition 5B50-5B71 Approved [5]
L-Tyrosine DM9O8DT Malnutrition 5B50-5B71 Approved [6]
Tetrahydrobiopterin DMINZ4W Malnutrition 5B50-5B71 Approved [7]
Metyrosine DMBYCU0 Pheochromocytoma 5A75 Approved [8]
L1-79 DMLHPVW Autism spectrum disorder 6A02 Phase 2 [9]
ProSavin DMJ42E6 Parkinson disease 8A00.0 Phase 1/2 [10]
OXB-102 DMXF9DM Parkinson disease 8A00.0 Phase 1/2 [11]
7,8-dihydrobiopterin DMQU4XM Discovery agent N.A. Investigative [12]
Meta-Tyrosine DM0748C Discovery agent N.A. Investigative [12]
3-iodotyrosine DMNZMH6 Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AGN-2979 DMLQRFO Psychotic disorder 6A20-6A25 Phase 2 [13]
KAR5585 DMXYN1H Pulmonary arterial hypertension BB01.0 Phase 1 [14]
fenclonine DMUBO3E Discovery agent N.A. Investigative [3]
6-fluorotryptophan DM6YD3U Discovery agent N.A. Investigative [15]
Drug Name Drug ID Indication ICD 11 Highest Status REF
fenclonine DMUBO3E Discovery agent N.A. Investigative [2]
6-fluorotryptophan DM6YD3U Discovery agent N.A. Investigative [15]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
L-Tryptophan hydroxylase 2 (TPH2) TT3KLDP TPH2_HUMAN Inhibitor [2]
Tryptophan 5-hydroxylase 1 (TPH1) TTZSJHV TPH1_HUMAN Inhibitor [3]
Tyrosine 3-monooxygenase (TH) TTUHP71 TY3H_HUMAN Inhibitor [4]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5095).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1242).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).
5 Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem. 2007;14(4):455-67.
6 Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5.
7 Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20.
8 Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul;18(1):1-8.
9 Effect of L1-79 on Core Symptoms of Autism Spectrum Disorder: A Case Series. Clin Ther. 2019 Oct;41(10):1972-1981.
10 Clinical pipeline report, company report or official report of Oxford BioMedica.
11 Clinical pipeline report, company report or official report of Oxford BioMedica.
12 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
13 Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7.
14 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
15 (+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9.