Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQKMX3)

Drug Name

alpha-propyldopacetamide Drug Info

Synonyms

alpha-Propyldopacetamide; 2-(3,4-Dihydroxyphenyl)pentanamide; 154-62-1; a-propyldopacetamide; Dihydroxyphenylvaleramide; EINECS 205-830-9; Benzeneacetamide,3,4-dihydroxy-a-propyl-,(aR)-; Benzeneacetamide,3,4-dihydroxy-a-propyl-,(aS)-; .alpha.-Propyldopacetamide; ACMC-20mn67; ACMC-20mn66; AC1Q5IT3; AC1L2R8E; GTPL5095; CTK8G6411; GDXQWRJYXZXWMT-UHFFFAOYSA-N; MolPort-003-894-618; KUC106729N; 2-(3,4-Dihydroxyphenyl)valeramide; AKOS024285098; a-propyl-3,4-dihydroxyphenyl-acetamide; MCULE-1302132273

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 101635
CAS Number: CAS 154-62-1
TTD Drug ID: DMQKMX3

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[5]
L-tyrosine	DM9O8DT	Malnutrition	5B50-5B71	Approved	[6]
Tetrahydrobiopterin	DMINZ4W	Malnutrition	5B50-5B71	Approved	[7]
Metyrosine	DMBYCU0	Pheochromocytoma	5A75	Approved	[8]
L1-79	DMLHPVW	Autism spectrum disorder	6A02	Phase 2	[9]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[10]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[11]
7,8-dihydrobiopterin	DMQU4XM	Discovery agent	N.A.	Investigative	[12]
Meta-Tyrosine	DM0748C	Discovery agent	N.A.	Investigative	[12]
3-iodotyrosine	DMNZMH6	Discovery agent	N.A.	Investigative	[4]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Tryptophan 5-hydroxylase 1 (TPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AGN-2979	DMLQRFO	Psychotic disorder	6A20-6A25	Phase 2	[13]
KAR5585	DMXYN1H	Pulmonary arterial hypertension	BB01.0	Phase 1	[14]
fenclonine	DMUBO3E	Discovery agent	N.A.	Investigative	[3]
6-fluorotryptophan	DM6YD3U	Discovery agent	N.A.	Investigative	[15]
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Drug(s) Targeting L-Tryptophan hydroxylase 2 (TPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
fenclonine	DMUBO3E	Discovery agent	N.A.	Investigative	[2]
6-fluorotryptophan	DM6YD3U	Discovery agent	N.A.	Investigative	[15]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
L-Tryptophan hydroxylase 2 (TPH2)	TT3KLDP	TPH2_HUMAN	Inhibitor	[2]
Tryptophan 5-hydroxylase 1 (TPH1)	TTZSJHV	TPH1_HUMAN	Inhibitor	[3]
Tyrosine 3-monooxygenase (TH)	TTUHP71	TY3H_HUMAN	Inhibitor	[4]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5095).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1242).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241).
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).
5	Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem. 2007;14(4):455-67.
6	Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5.
7	Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20.
8	Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul;18(1):1-8.
9	Effect of L1-79 on Core Symptoms of Autism Spectrum Disorder: A Case Series. Clin Ther. 2019 Oct;41(10):1972-1981.
10	Clinical pipeline report, company report or official report of Oxford BioMedica.
11	Clinical pipeline report, company report or official report of Oxford BioMedica.
12	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
13	Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7.
14	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
15	(+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9.