Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQLZOF)

Drug Name
PF-06252616 Drug Info
Indication
Disease Entry ICD 11 Status REF
Duchenne dystrophy 8C70 Phase 2 [1]
Muscular dystrophy 8C70 Phase 2 [2]
Cross-matching ID
TTD Drug ID
DMQLZOF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Growth/differentiation factor 8 (GDF-8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LY2495655 DMM5JAN Disuse muscle atrophy 8B61 Phase 2 [3]
AMG 745 DMFXN2T Muscle atrophy FB32.Y Phase 2 [4]
SAR391786 DMS1YPZ Muscle atrophy FB32.Y Phase 2 [5]
Domagrozumab DMCT08V Duchenne dystrophy 8C70 Phase 2 [6]
ACE-031 DMZ8PY0 Duchenne dystrophy 8C70 Phase 2 [7]
Stamulumab DMBCIXL Duchenne dystrophy 8C70 Phase 1/2 [3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Growth/differentiation factor 8 (GDF-8) TTSWPH8 GDF8_HUMAN Not Available [3]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT02310763) A Phase 2 Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of PF-06252616 in Duchenne Muscular Dystrophy. U.S. National Institutes of Health.
3 Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders. Curr Opin Support Palliat Care. 2013 November; 7(4): 352-360.
4 The role of myostatin in muscle wasting: an overview. J Cachexia Sarcopenia Muscle. 2011 September; 2(3): 143-151.
5 Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact. 2010 Mar;10(1):56-63.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers. Muscle Nerve. 2013 Mar;47(3):416-23.