General Information of Drug (ID: DMQSNV8)

Drug Name
TgAAV-CFTR Drug Info
Synonyms TgAAV-CF; Gene therapy (CFTR), Targeted Genetics; Gene therapy (CFTR), Targeted Genetics/Celltech
Indication
Disease Entry ICD 11 Status REF
Cystic fibrosis CA25 Discontinued in Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMQSNV8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TM-601 DMKV5UM Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
Lancovutide DM7MBV6 Chronic obstructive pulmonary disease CA22 Phase 2 [4]
131I-TM-601 DMTIED1 Glioma 2A00.0 Phase 2 [5]
BLZ-100 DMFKA4G Glioma 2A00.0 Phase 1/2 [6]
GR-213487 DMCXLIK Cystic fibrosis CA25 Discontinued in Phase 2 [7]
Endovion DMJU39N Solid tumour/cancer 2A00-2F9Z Terminated [8]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Chloride channel unspecific (ClC) TTCYAXN NOUNIPROTAC Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011201)
2 Novel molecular approaches to cystic fibrosis gene therapy. Biochem J. 2005 April 1; 387(Pt 1): 1-15.
3 NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels. Biochemistry. 1995 Jan 10;34(1):13-21.
4 Airway-rehydrating agents for the treatment of cystic fibrosis: past, present, and future. Ann Pharmacother. 2011 Jan;45(1):49-59.
5 Imaging glioma extent with 131I-TM-601. J Nucl Med. 2005 Apr;46(4):580-6.
6 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
7 EP patent application no. 1336602, Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases.
8 Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas. J Membr Biol. 2003 Nov 15;196(2):83-94.