Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQSNV8)

Drug Name

TgAAV-CFTR Drug Info

Synonyms

TgAAV-CF; Gene therapy (CFTR), Targeted Genetics; Gene therapy (CFTR), Targeted Genetics/Celltech

Indication

Disease Entry	ICD 11	Status	REF
Cystic fibrosis	CA25	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Chloride channel unspecific (ClC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TM-601	DMKV5UM	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
Lancovutide	DM7MBV6	Chronic obstructive pulmonary disease	CA22	Phase 2	[4]
131I-TM-601	DMTIED1	Glioma	2A00.0	Phase 2	[5]
BLZ-100	DMFKA4G	Glioma	2A00.0	Phase 1/2	[6]
GR-213487	DMCXLIK	Cystic fibrosis	CA25	Discontinued in Phase 2	[7]
Endovion	DMJU39N	Solid tumour/cancer	2A00-2F9Z	Terminated	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Chloride channel unspecific (ClC)	TTCYAXN	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011201)
2	Novel molecular approaches to cystic fibrosis gene therapy. Biochem J. 2005 April 1; 387(Pt 1): 1-15.
3	NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels. Biochemistry. 1995 Jan 10;34(1):13-21.
4	Airway-rehydrating agents for the treatment of cystic fibrosis: past, present, and future. Ann Pharmacother. 2011 Jan;45(1):49-59.
5	Imaging glioma extent with 131I-TM-601. J Nucl Med. 2005 Apr;46(4):580-6.
6	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
7	EP patent application no. 1336602, Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases.
8	Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas. J Membr Biol. 2003 Nov 15;196(2):83-94.