Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQURWZ)

Drug Name
Indole-based analog 14 Drug Info
Synonyms PMID27410995-Compound-Figure3a
Cross-matching ID
PubChem CID
53246690
TTD Drug ID
DMQURWZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Ribosomal protein S6 kinase alpha-3 (RSK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27410995-Compound-Figure3j DMJRZLB N. A. N. A. Patented [1]
Pyrrolo[2,3-d]pyrimidine derivative 35 DMXU08A N. A. N. A. Patented [1]
BI-D1870 DMK3SAF Chronic lymphocytic leukaemia 2A82.0 Preclinical [2]
PMID22765894C8h DMH5RFU Discovery agent N.A. Investigative [3]
PMID22564207C25b DMBMYKQ Discovery agent N.A. Investigative [4]
BIX 02565 DMNAX1Q Discovery agent N.A. Investigative [5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ribosomal protein S6 kinase alpha-3 (RSK3) TTUM2ZR KS6A3_HUMAN Inhibitor [1]

References

1 Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78.
2 BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401(1):29-38.
3 The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85.
4 Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93.
5 Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity. Bioorg Med Chem Lett. 2012 Jan 1;22(1):738-42.