Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQZJ3B)

Drug Name

Anti-HIV ribozyme therapy Drug Info

Synonyms

OZ1; RRZ2; HIV ribozyme gene therapy, Gene Shears; Gene therapy (HIV), Gene Shears; Anti-HIV ribozyme therapy, Johnson & Johnson; Anti-HIV-1 gene transfer product, Johnson & Johnson

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Phase 1/2	[1]

Cross-matching ID

TTD Drug ID: DMQZJ3B

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Tat protein (HIV tat)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[3]
Ro-24-7429	DMA2UYE	Human immunodeficiency virus infection	1C62	Phase 2	[4]
ALX-40-4C	DMV934L	Human immunodeficiency virus infection	1C62	Phase 2	[5]
EM-2487	DMG9R8E	Human immunodeficiency virus infection	1C62	Terminated	[6]
Durhamycin A	DM29PTO	Discovery agent	N.A.	Investigative	[7]
CGP 40336A	DMEA5BZ	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Tat protein (HIV tat)	TTT3ZC9	TAT_HV1H2	Modulator	[2]

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References

1	Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt. Stem Cells Int. 2011;2011:393698.
2	Clinical gene therapy research utilizing ribozymes: application to the treatment of HIV/AIDS. Methods Mol Biol. 2004;252:581-98.
3	Docking studies reveal a selective binding of D-penicillamine to the transactivator protein of human immunodeficiency virus type 1. FEBS Lett. 2002 Apr 10;516(1-3):43-6.
4	A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. The AIDS Clinical Trials Group 213 Team. J Infect Dis. 1995 Nov;172(5):1246-52.
5	Anti-human immunodeficiency virus type 1 activity of an oligocationic compound mediated via gp120 V3 interactions. J Virol. 1996 May;70(5):2825-31.
6	EM2487, a novel anti-HIV-1 antibiotic, produced by Streptomyces sp. Mer-2487: taxonomy, fermentation, biological properties, isolation and structure elucidation. J Antibiot (Tokyo). 1999 Nov;52(11):971-82.
7	Durhamycin A, a potent inhibitor of HIV Tat transactivation. J Nat Prod. 2002 Aug;65(8):1091-5.
8	RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86.