Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR3XDH)

Drug Name

VCB102 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Psoriasis vulgaris	EA90	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Cysteines of Keap1 (KEAP1 Cysteines)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CXA10	DMM7Z6K	Focal segmental glomerulosclerosis	MF8Y	Phase 2	[3]
PMID28454500-Compound-8	DM6BQFA	N. A.	N. A.	Patented	[4]
Pyrazino[2,1-a]isoquinolin derivative 4	DMKTNBC	N. A.	N. A.	Patented	[4]
PMID28454500-Compound-36	DM5RZWG	N. A.	N. A.	Patented	[4]
Chalcone derivative 4	DM45COR	N. A.	N. A.	Patented	[4]
2-hydroxybenzamide derivative 1	DMER2ZQ	N. A.	N. A.	Patented	[4]
Vinyl sulfone derivative 1	DMTMFNK	N. A.	N. A.	Patented	[4]
Pyrazino[2,1-a]isoquinolin derivative 2	DMYXKQ3	N. A.	N. A.	Patented	[4]
Diterpenoid derivative 1	DMAZOH4	N. A.	N. A.	Patented	[4]
PMID28454500-Compound-13	DM7SIVA	N. A.	N. A.	Patented	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cysteines of Keap1 (KEAP1 Cysteines)	TT3Z6Y9	KEAP1_HUMAN	Inactivator	[2]

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References

1	Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov. 2019 Apr;18(4):295-317.
2	NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases. Biomolecules. 2020 Jun 14;10(6):904.
3	The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophys Rev. 2017 Feb;9(1):41-56.
4	Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785.