Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR7BAO)

Drug Name

PRN1371 Drug Info

Synonyms

PUIXMSRTTHLNKI-UHFFFAOYSA-N; 1802929-43-6; PRN-1371; UNII-S3OPE9IA3Q; S3OPE9IA3Q; 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one; GTPL9788; US9567334, Example 6; SCHEMBL16993012; BDBM286984; BCP20493; s8578; AKOS032954157; CS-7485; compound 34 [PMID: 28665128]; HY-101768; J3.662.238E; 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

PubChem CID: 118295624
CAS Number: CAS 1802929-43-6
TTD Drug ID: DMR7BAO

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Fibroblast growth factor receptor (FGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erdafitinib	DMI782S	Bladder cancer	2C94	Approved	[2]
Futibatinib	DMWM4D0	Intrahepatic cholangiocarcinoma	2C12.10	Approved	[3]
Infigratinib	DMNKBEC	Cholangiocarcinoma	2C12.10	Approved	[1]
HIF-1alpha	DM4OQRD	Lymphoma	2A80-2A86	Phase 4	[4]
ARQ-087	DM02BVQ	Intrahepatic cholangiocarcinoma	2C12.10	Phase 3	[1]
AZD4547	DM3827C	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[1]
Debio 1347	DMZW50O	Solid tumour/cancer	2A00-2F9Z	Phase 2	[5]
BAY1163877	DMCSGJ2	Bladder cancer	2C94	Phase 2	[6]
ICP-192	DM524GR	Bladder cancer	2C94	Phase 2	[7]
PD173074	DMP0N4U	Nasopharyngeal carcinoma	2B6B	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fibroblast growth factor receptor (FGFR)	TT0LF7H	NOUNIPROTAC	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
3	TAS-120, a highly potent and selective irreversible FGFR inhibitor, is effective in tumors harboring various FGFR gene abnormalities. Molecular Cancer Therapeutics. 01/2014; 12(11_Supplement):A270-A270.
4	Tumor angiogenesis as a therapeutic target. Drug Discov Today. 2001 Oct 1;6(19):1005-1024.
5	The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor. Mol Cancer Ther. 2014 Nov;13(11):2547-58.
6	Preclinical profile of BAY 1163877 - a selective pan-FGFR inhibitor in phase 1 clinical trial. Cancer Research. 10/2014; 74(19 Supplement):1739-1739.
7	Clinical pipeline report, company report or official report of InnoCare Pharma.