Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR9OD1)

• Drug Name: Angiotensin IV Drug Info
• Synonyms: Nle-angiv; Human angiotensin IV; Ile3-angiotensin IV; Huamn angiotensin (3-8); Ang IV; VAL-TYR-ILE-HIS-PRO-PHE; Angiotensin II (3-8), human; 1-De-asp-2-de-arg-5-ile-angiotensin II; (Ile5)-angiotensin II (3-8); Human angiotensin hexapeptide (3-8); (3-8)-5-Isoleucine-angiotensin II; (Des(Asp1,Arg2)-Ile5)angiotensin II; (Isoleucine5)-angiotensin II hexapeptide; CHEMBL261120; 12676-15-2; 5-Isoleucine-angiotensin II 3-8-hexapeptide; 23025-68-5; ANGIOTENSIN I/II (3-8); Angiotensin II (3-8); MLS000069773

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 123814
  ChEBI ID: CHEBI:80127
  CAS Number: CAS 23025-68-5
  TTD Drug ID: DMR9OD1

Molecule-Related Drug Atlas

Drug(s) Targeting Aminopeptidase N (ANPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IP10 C8	DMANRGW	Psoriasis vulgaris	EA90	Phase 2	[3]
[(125)I] RB129	DMX0G7E	Discovery agent	N.A.	Investigative	[4]
KELATORPHAN	DMOX8FD	Discovery agent	N.A.	Investigative	[5]
(1-Amino-3-phenyl-propyl)-phosphinic acid	DMXD697	Discovery agent	N.A.	Investigative	[6]
N1-(3,3-diphenylpropyl)-N3-hydroxymalonamide	DM5F04D	Discovery agent	N.A.	Investigative	[7]
N1-(4-chlorobenzyl)-2-benzyl-N3-hydroxymalonamide	DMTMDZ4	Discovery agent	N.A.	Investigative	[7]
N1,2-dibenzyl-N3-hydroxy-N1-phenethylmalonamide	DM1L89K	Discovery agent	N.A.	Investigative	[7]
1-aminohexylphosphonic acid	DMFUABI	Discovery agent	N.A.	Investigative	[8]
(S)-2-Amino-3-phenyl-propane-1-thiol	DMMAUKO	Discovery agent	N.A.	Investigative	[6]
(Amino-phenyl-methyl)-phosphinic acid	DMS4ZVK	Discovery agent	N.A.	Investigative	[6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aminopeptidase N (ANPEP)	TTPHMWB	AMPN_HUMAN	Inhibitor	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5368).
• [2] Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2. Bioorg Med Chem. 2008 Jul 15;16(14):6924-35.
• [3] Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin Chem Lab Med. 2009;47(3):253-61.
• [4] Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography. Biochimie. 2004 Feb;86(2):105-13.
• [5] Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem. 1988 Sep;31(9):1825-31.
• [6] Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6.
• [7] Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34.
• [8] New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2010 Apr 15;18(8):2930-6.