Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR9XMZ)

Drug Name
BBP-671 Drug Info
Indication
Disease Entry ICD 11 Status REF
Methylmalonic acidemia 5C50.E0 Phase 1 [1]
Propionic acidemia 5C50.E0 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMR9XMZ

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Pantothenate kinase 3 (PANK3) TTFBUWA PANK3_HUMAN Activator [2]

References

1 ClinicalTrials.gov (NCT04836494) A First-in-human, Randomized, Placebo-controlled, Single and Multiple Ascending Dose Escalation to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BBP-671 in Healthy Subjects and In Patients With Propionic Acidemia or Methylmalonic Acidemia. U.S.National Institutes of Health.
2 Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia. J Inherit Metab Dis. 2023 Jan;46(1):28-42.