Details of the Drug-Related molecule(s) Interaction Atlas

US9598431, 3 Drug Info

SCHEMBL18580158; BDBM302860; (2S)-1-(3-Thienyl)propan-2-ol; US9598431, 3

Cross-matching ID

PubChem CID

126644564

TTD Drug ID

DMRC4O7

General Information of Drug (ID: DMRC4O7)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Nuclear receptor ROR-alpha (RORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SR1078	DM7MDZE	Liver cancer	2C12	Preclinical	[2]
SR3335	DM96IUW	Type-2 diabetes	5A11	Preclinical	[3]
7-hydroxycholesterol	DMZXMB7	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nuclear receptor ROR-alpha (RORA)	TT1TYN7	RORA_HUMAN	Inhibitor	[1]

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References

1	Compounds useful for inhibiting ROR-gamma-t. US9598431.
2	Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORalpha and ROR. ACS Chem Biol. 2010 Nov 19;5(11):1029-34.
3	Identification of SR3335 (ML-176): a synthetic RORalpha selective inverse agonist. ACS Chem Biol. 2011 Mar 18;6(3):218-22.
4	Identification of natural ligands of retinoic acid receptor-related orphan receptor alpha ligand-binding domain expressed in Sf9 cells--a mass spectrometry approach. Anal Biochem. 2003 Dec 1;323(1):139-49.