Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRDEKZ)

Drug Name

LY2928057 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Anaemia	3A90	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Solute carrier family 40 member 1 (SLC40A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ferroportin mab	DM13YK0	Anemia	3A00-3A9Z	Phase 1	[3]
M012	DME6UNO	Myelodysplastic syndrome	2A37	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 40 member 1 (SLC40A1)	TT6Y1PG	S40A1_HUMAN	Modulator	[2]

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References

1	Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423.
2	Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation. Am J Hematol. 2012 April; 87(4): 392-400.
3	The pathophysiology and pharmacology of hepcidin. Trends Pharmacol Sci. 2014 March; 35(3): 155-161.
4	Hepcidin agonists as therapeutic tools. Blood. 2018 Apr 19;131(16):1790-1794.