Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRDNPC)

Drug Name

GS-6620 Drug Info

Synonyms

GS-441326; NS5B polymerase inhibitor (HCV infection), Gilead Sciences

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PSI-7977	DMLSUWZ	HCV 1-6 infection	1E51	Approved	[3]
Setrobuvir	DMTNDM2	Hepatitis C virus infection	1E51.1	Phase 2	[4]
BI 207127	DMMSGAT	Hepatitis C virus infection	1E51.1	Phase 2	[5]
Valopicitabine dihydrochloride	DMFWZ2U	Virus infection	1A24-1D9Z	Phase 2	[6]
INX-189	DMSTJ6Q	Hepatitis C virus infection	1E51.1	Phase 2	[7]
Tegobuvir	DM6YI5T	Hepatitis C virus infection	1E51.1	Phase 2	[8]
VX-759	DMJUSM8	Hepatitis C virus infection	1E51.1	Phase 2	[9]
VX-135	DMZ3FE8	Hepatitis C virus infection	1E51.1	Phase 2	[10]
VX-222	DMO3U4W	Hepatitis C virus infection	1E51.1	Phase 2	[9]
BMS 791325	DMKH4PI	Hepatitis C virus infection	1E51.1	Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B)	TTMVBWH	POLG_HCV1	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT01316237) A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naive Subjects With Chronic Hepatitis C Virus Infection. U.S. National Institutes of Health.
2	Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrob Agents Chemother. 2014;58(4):1930-42.
3	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
4	Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011).
5	2011 Pipeline of Boehringer Ingelheim Pharma.
6	Valopicitabine dihydrochloride:a specific polymerase inhibitor of hepatitis C virus. Curr Opin Investig Drugs. 2007 Feb;8(2):150-8.
7	Clinical pipeline report, company report or official report of Bristol-Myers Squibb.
8	Clinical pipeline report, company report or official report of Gilead (2011).
9	2011 Pipeline of Vertex.
10	All-oral HCV therapies near approval. Nat Rev Drug Discov. 2013 Jun;12(6):409-11.
11	2011 Pipeline of Bristol-Myers Squibb.