General Information of Drug (ID: DMRDNPC)

Drug Name
GS-6620 Drug Info
Synonyms GS-441326; NS5B polymerase inhibitor (HCV infection), Gilead Sciences
Indication
Disease Entry ICD 11 Status REF
Hepatitis C virus infection 1E51.1 Phase 1 [1]
Cross-matching ID
PubChem CID
58059494
CAS Number
CAS 1350735-70-4
TTD Drug ID
DMRDNPC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PSI-7977 DMLSUWZ HCV 1-6 infection 1E51 Approved [3]
Setrobuvir DMTNDM2 Hepatitis C virus infection 1E51.1 Phase 2 [4]
BI 207127 DMMSGAT Hepatitis C virus infection 1E51.1 Phase 2 [5]
Valopicitabine dihydrochloride DMFWZ2U Virus infection 1A24-1D9Z Phase 2 [6]
INX-189 DMSTJ6Q Hepatitis C virus infection 1E51.1 Phase 2 [7]
Tegobuvir DM6YI5T Hepatitis C virus infection 1E51.1 Phase 2 [8]
VX-759 DMJUSM8 Hepatitis C virus infection 1E51.1 Phase 2 [9]
VX-135 DMZ3FE8 Hepatitis C virus infection 1E51.1 Phase 2 [10]
VX-222 DMO3U4W Hepatitis C virus infection 1E51.1 Phase 2 [9]
BMS 791325 DMKH4PI Hepatitis C virus infection 1E51.1 Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) TTMVBWH POLG_HCV1 Inhibitor [2]

References

1 ClinicalTrials.gov (NCT01316237) A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naive Subjects With Chronic Hepatitis C Virus Infection. U.S. National Institutes of Health.
2 Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrob Agents Chemother. 2014;58(4):1930-42.
3 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
4 Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011).
5 2011 Pipeline of Boehringer Ingelheim Pharma.
6 Valopicitabine dihydrochloride:a specific polymerase inhibitor of hepatitis C virus. Curr Opin Investig Drugs. 2007 Feb;8(2):150-8.
7 Clinical pipeline report, company report or official report of Bristol-Myers Squibb.
8 Clinical pipeline report, company report or official report of Gilead (2011).
9 2011 Pipeline of Vertex.
10 All-oral HCV therapies near approval. Nat Rev Drug Discov. 2013 Jun;12(6):409-11.
11 2011 Pipeline of Bristol-Myers Squibb.