Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRF5LU)

Drug Name

IC-041 Drug Info

Synonyms

Small molecule PDE 1 inhibitors (cognitive disorder), Intra-Cellular Therapies; PDE 1B inhibitor (small molecule therapeutic, cognitive disorder), Intra-Cellular

Indication

Disease Entry	ICD 11	Status	REF
Cognitive impairment	6D71	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMRF5LU

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

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Drug(s) Targeting Phosphodiesterase 1B (PDE1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US10034861, Example 165	DMD8FS5	N. A.	N. A.	Patented	[2]
US10092575, Example 101	DMU8CAD	N. A.	N. A.	Patented	[3]
US10034861, Example 164	DM27SFD	N. A.	N. A.	Patented	[2]
AC1MOZOL	DM6293C	N. A.	N. A.	Patented	[4]
US9073936, 1	DMZD1L5	N. A.	N. A.	Patented	[5]
US9073936, 2	DMZH3MX	N. A.	N. A.	Patented	[5]
US10092575, Example 158	DM7MNE2	N. A.	N. A.	Patented	[3]
AC1LDDOQ	DMKTMCH	N. A.	N. A.	Patented	[3]
US10034861, Example 1	DMLJV01	N. A.	N. A.	Patented	[2]
US10092575, Example 141	DMT47DF	N. A.	N. A.	Patented	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 1B (PDE1B)	TT3ZS42	PDE1B_HUMAN	Inhibitor	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1295).
2	1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors. US10034861.
3	Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds. US10092575.
4	Inhibitors of phosphodiesterase 11 (PDE11). US9173884.
5	Organic compounds. US9598426.
6	Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6h)-ones. US10105367.