Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRF73O)

Drug Name

HT-2678 Drug Info

Synonyms

GABA inverse agonist (cognitive disorder) Helicon; HT-4313; GABA A receptor alpha-5 subunit modulator (cognitive disorder), Helicon Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Cognitive impairment	6D71	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting GABA(A) receptor alpha-5 (GABRA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[1]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[2]
Basmisanil	DMQ8J0U	Alzheimer disease	8A20	Phase 2	[3]
RG-7816	DMD16JK	Autism spectrum disorder	6A02	Phase 1	[4]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[1]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[5]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[6]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[1]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[7]
[3H]CGS8216	DMLP68J	Inflammation	1A00-CA43.1	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408).
2	New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide. J Med Chem. 1980 Jun;23(6):702-4.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
5	Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4.
6	The GABA(A) receptor as a target for photochromic molecules. Bioorg Med Chem. 2010 Nov 15;18(22):7731-8.
7	Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABA... J Med Chem. 1996 Apr 26;39(9):1928-34.