Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRN543)

Drug Name

ISIS-EIF4E Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25.Y	Phase 2	[1]
Prostate cancer	2C82.0	Phase 2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting eIF4E-BP2 messenger RNA (eIF4E-BP2 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 232828	DMYEPV8	Discovery agent	N.A.	Investigative	[3]
ISIS 347577	DM36SRT	Discovery agent	N.A.	Investigative	[3]
ISIS 347573	DMAFEX8	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
eIF4E-BP2 messenger RNA (eIF4E-BP2 mRNA)	TTNBTCW	4EBP2_HUMAN	Not Available	[2]

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References

1	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
2	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
3	US patent application no. 7,468,431, Modulation of eIF4E-BP2 expression.