Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRO6XT)

Drug Name

BGB-290 Drug Info

Synonyms

Pamiparib

Indication

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Phase 2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]
Recurrent glioblastoma	2A00.00	Phase 1	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Poly [ADP-ribose] polymerase (PARP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[4]
Rucaparib	DM9PVX8	Ovarian cancer	2C73	Approved	[5]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[6]
MK-4827	DMLYGH4	Ovarian cancer	2C73	Phase 3	[7]
BSI-201	DMM0VO3	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
Rubraca rucaparib	DM25TMP	Ovarian cancer	2C73	Phase 3	[2]
ABT-888	DM4HYMS	Breast cancer	2C60-2C65	Phase 3	[7]
INO-1001	DM5L8QT	Brain cancer	2A00	Phase 3	[9]
BGP-15	DMYDM68	Type-2 diabetes	5A11	Phase 2	[10]
2X-121	DMX9MSL	Breast cancer	2C60-2C65	Phase 2	[2]
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Drug(s) Targeting Tankyrase (TNKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2X-121	DMX9MSL	Breast cancer	2C60-2C65	Phase 2	[2]
STP1002	DMXCJP8	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Poly [ADP-ribose] polymerase (PARP)	TTEBCY8	NOUNIPROTAC	Inhibitor	[2]
Tankyrase (TNKS)	TTKSAQZ	NOUNIPROTAC	Modulator	[3]

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References

1	ClinicalTrials.gov (NCT03933761) Pamiparib in Fusion Positive, Reversion Negative High Grade Serous Ovarian Cancer or Carcinosarcoma With BRCA1/2 Gene Mutations If Progression on Substrate Poly ADP Ribose Polymerase Inhibitbor (PARPI) or Chemotherapy (PRECISE). U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	National Cancer Institute Drug Dictionary (drug id 769217).
4	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
5	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
6	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
7	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
8	Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro. Clin Cancer Res. 2012 Mar 15;18(6):1655-62.
9	Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. Shock. 2010 May;33(5):507-12.
10	BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases. Mol Cell Biochem. 2012 Jun;365(1-2):129-37.
11	Design and development of a tankyrase inhibitor STP06-1002 as an anticancer therapeutic agent. Cancer Res 2017;77(13 Suppl):Abstract nr 5171.