Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMROQP6)

• Drug Name: MRS2957 Drug Info
• Synonyms: MRS 2957

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 91827347
  TTD Drug ID: DMROQP6

Molecule-Related Drug Atlas

Drug(s) Targeting P2Y purinoceptor 6 (P2RY6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GC021109	DMQBEYV	Alzheimer disease	8A20	Phase 1	[3]
INS 316	DMTHMEI	Lung cancer	2C25.0	Discontinued in Phase 3	[4]
adenosine diphosphate	DMFUHKP	N. A.	N. A.	Investigative	[4]
2MeSATP	DMUE0W6	Discovery agent	N.A.	Investigative	[4]
RB 2	DMCEFUW	Discovery agent	N.A.	Investigative	[5]
PSB-0952	DMW19LB	Discovery agent	N.A.	Investigative	[5]
5BrUTP	DMEVRH4	Discovery agent	N.A.	Investigative	[4]
MRS2782	DMZSO4R	Discovery agent	N.A.	Investigative	[6]
MRS2578	DMKMPS6	Discovery agent	N.A.	Investigative	[7]
UDP-beta-S	DMMWHAV	Discovery agent	N.A.	Investigative	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
P2Y purinoceptor 6 (P2RY6)	TTNVSKA	P2RY6_HUMAN	Agonist	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5903).
• [2] Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. J Med Chem. 2010 Jun 10;53(11):4488-501.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8.
• [5] Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86.
• [6] Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg Med Chem. 2008 Jun 15;16(12):6319-32.
• [7] Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol. 2004 May 1;67(9):1763-70.
• [8] P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13(3):289-312.