Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRQSN2)

Drug Name

IDN-1965 Drug Info

Synonyms

IDN-1965; GONUYDANRODTCF-IBYPIGCZSA-N; IDN 1965; 204919-14-2; CHEMBL198068; SCHEMBL5668068; LS-101833; N-[(1.3-dimethylindole-2-carbonyl)valinyl]-3-amino-4-oxo-5-fluoropentanoic Acid; N-[(1,3-Dimethylindole-2-Carbonyl)Valinyl]-3-Amino-4-Oxo-5-Fluoropentanoic Acid; Pentanoic acid, 3-(((2S)-2-(((1,3-dimethyl-1H-indol-2-yl)carbonyl)amino)-3-methyl-1-oxobutyl)amino)-5-fluoro-4-oxo-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9802179
CAS Number: CAS 204919-14-2
TTD Drug ID: DMRQSN2

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Caspase (CASP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NCX-1000	DM2YIZH	Cardiovascular disease	BA00-BE2Z	Phase 2	[2]
Z-VAD-fmk	DMTDG7L	Pulmonary fibrosis	CB03.4	Preclinical	[3]
VX-166	DMZKY56	Hepatic fibrosis	DB93.0	Preclinical	[4]
ALS-769	DMGBT9Z	Solid tumour/cancer	2A00-2F9Z	Terminated	[5]
Isoquinoline-1,3,4(2H)-trione	DMT4RI2	Discovery agent	N.A.	Investigative	[6]
Ac-DEVD-CHO	DMW02H7	Discovery agent	N.A.	Investigative	[7]
2-aminophenoxazine-3-one	DMBVGAO	T-cell leukaemia	2A90	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Caspase (CASP)	TTZY5KP	NOUNIPROTAC	Inhibitor	[1]

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References

1	Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic ... Circulation. 2003 Dec 16;108(24):3036-41.
2	Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice. Br J Pharmacol. 2004 Sep;143(1):33-42.
3	Clinical pipeline report, company report or official report of InvivoGen.
4	VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis. Crit Care. 2009;13(5):R146.
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025089)
6	Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23.
7	Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. Eur J Med Chem. 2010 Sep;45(9):3858-63.
8	Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197.